The practice of fecal microbiota transplantation in inflammatory bowel disease

Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the te...

Full description

Saved in:
Bibliographic Details
Published inIntestinal research (Intest Res) Vol. 22; no. 1; pp. 44 - 64
Main Authors Umang Arora, Saurabh Kedia, Vineet Ahuja
Format Journal Article
LanguageKorean
Published 대한장연구학회 30.01.2024
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:Current evidence posits a central role for gut microbiota and the metabolome in the pathogenesis and progression of inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been established as a means to manipulate this microbiome safely and sustainably. Several aspects of the technical improvement including pretreatment with antibiotics, use of frozen stool samples as well as short donor-to-recipient time are proposed to improve its response rates. Its efficacy in ulcerative colitis has been proven in clinical trials while data is emerging for Crohn’s disease. This review describes briefly the biology behind FMT, the available evidence for its use in IBD, and the host, recipient and procedural factors which determine the clinical outcomes. (Intest Res 2024;22:44-64)
Bibliography:Korean Association for the Study of Intestinal Disease
ISSN:1598-9100