The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism

Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protec...

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Published inKidney research and clinical practice Vol. 42; no. 5; pp. 561 - 578
Main Authors Orestes Foresto-neto, Ana Ruth Paolinetti Alves Da Silva, Marcella Cipelli, Fernanda Paula Roncon Santana-novelli, Niels Olsen Saraiva Camara
Format Journal Article
LanguageKorean
Published 대한신장학회 30.09.2023
Subjects
Immune system
Lung injury
Metabolismx
Microbiota
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Summary:Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protects the kidneys or participates in the pathogenesis of renal diseases is unclear. Several studies have indicated that HIF signaling promotes fibrosis in experimental models of kidney disease. Other reports showed a protective effect of HIF activation on kidney inflammation and injury. In addition to the direct effect of HIF on the kidneys, experimental evidence indicates that HIF-mediated metabolic shift activates inflammatory cells, supporting the HIF cascade as a link between lung or gut damage and worsening of renal disease. Although hypoxia and HIF activation are present in several scenarios of renal diseases, further investigations are needed to clarify whether interfering with the HIF pathway is beneficial in different pathological contexts.
Bibliography:The Korean Society of Nephrology
ISSN:2211-9132