국내 원발성 식도 악성 흑색종: 임상 양상, 치료 및 예후

• Published in: The Korean journal of gastroenterology Vol. 79; no. 5; pp. 222 - 227
• Main Authors: 오형훈, Hyung-hoon Oh, 정용욱, Yong-wook Jung, 한보라, Bora Han, 임찬묵, Chan-muk Im, 유형주, Hyung-joo Yu, 주영은, Young-eun Joo
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 31.05.2022
• Subjects: Esophagus; Korea; Melanoma
• ISSN: 1598-9992

Primary esophageal melanoma is a rare disease with a poor prognosis. To date, 18 cases have been reported in Korea. Four patients visited the Chonnam National University Hwasun Hospital with dysphagia, followed by epigastric pain and discomfort, odynophagia, and weight loss. Esophagogastroduodenoscopy revealed a black pigmented polypoid mass, protruding mass, or black-pigmented flat lesions. Two patients had distant metastases and lymphadenopathies in imaging studies. Two patients underwent esophagectomy and intrathoracic esophagogastrostomy. One patient was treated with chemotherapy and interferon-alpha. The other patient declined further treatment. The routine histology using H&E revealed brown-colored atypical melanocytes. Immunohistochemical staining exhibited strong reactivity for Melan-A, S-100, and HMB-45 proteins. The biopsy specimens were interpreted to be malignant melanoma. One patient had multiple distant metastases 13 months after surgery. The other patient had no recurrence for 33 months after surgery. The patient treated with chemotherapy and interferon-alpha showed disease progression in the follow-up examination. Primary esophageal melanoma in Korea is a rare disease characterized by aggressive behavior, early metastasis, and poor prognosis. (Korean J Gastroenterol 2022;79:222-227)