Long-term survival of children following acute peritoneal dialysis in a resource-limited setting

• Published in: Kidney research and clinical practice Vol. 39; no. 4; pp. 469 - 478
• Main Authors: Michael Abel Alao, Olayinka Rasheed Ibrahim, Adanze Onyenonachi Asinobi, Akinwale Akinsola
• Format: Journal Article
• Language: Korean
• Published: 대한신장학회 31.12.2020
• Subjects: Acute kidney injury; Child; Chronic kidney disease; Peritoneal dialysis; Survival
• ISSN: 2211-9132

Background: There is a paucity of data on long term-outcomes of children who undergo acute peritoneal dialysis (PD) in resource-limited settings. We reviewed the outcomes of children who underwent PD after 18 months of follow-up. Methods: We conducted a prospective cohort study in children with acute kidney injury (AKI) who underwent PD. Diagnosis of AKI was based on the 2012 Kidney Disease: Improving Global Outcomes definition. We assessed outcomes of in-hospital mortality, 18-month post-dialysis survival, factors associated with survival, and progression to chronic kidney disease (CKD). Results: Twenty-nine children with a median age of 6 (3 to 11) years underwent acute PD. In-hospital mortality was 3/29 (10.3%) and rose to 27.6% during follow-up. Seven (24.1%) children were lost to follow-up. Of the 14 remaining children, six (42.9%) experienced full recovery of renal function, while eight (57.1%) progressed to CKD. Among those who experienced full recovery, median (interquartile range) estimated glomerular filtration rate (eGFR) rose from 12.67 (7.05, 22.85) mL/min/1.73 m 2 to 95.56 (64.50, 198.00) mL/min/1.73 m 2 , P = 0.031. No significant changes in median eGFR from baseline were observed among those who progressed to CKD (P = 0.383) or in non-survivors (P = 0.838). According to Kaplan-Meier curve analyses, 18-month survival during follow-up was 66.0% (95% CI, 45.0% to 86.5%). Age < 5 was associated with greater likelihood of survival (OR, 3.217; 95% CI, 1.240 to 8.342). Conclusion: Progression of post-PD AKI to CKD occurred in more than half of survivors. Age < 5 was associated with greater likelihood of survival.