Amino Acid Transporters as Potential Therapeutic Targets in Thyroid Cancer

Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called “C-cells”), via amino acid transporters. Amino acid transporters up-regulat...

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Bibliographic Details
Published inEndocrinology and metabolism (Seoul) Vol. 35; no. 2; pp. 227 - 236
Main Authors Keisuke Enomoto, Muneki Hotomi
Format Journal Article
LanguageKorean
Published 대한내분비학회 30.06.2020
Subjects
2-amino-3
3
4
5-amino-2-phenylbenzo
5-dichlorophenyl
Amino acid transport systems
Boron neutron capture therapy
d
Large neutral amino acid-transporter 1
methoxy
oxazol-7-yl
propanoic acid
Proto-on-cogene proteins c-myc
Thyroid neoplasms
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Summary:Thyroid cancer cells have a high amino acid demand for proliferation, invasion, and metastasis. Amino acids are taken up by thyroid cancer cells, both thyroid follicular cell and thyroid parafollicular cells (commonly called “C-cells”), via amino acid transporters. Amino acid transporters up-regulate in many cancers, and their expression level associate with clinical aggressiveness and prognosis. This is the review to discuss the therapeutic potential of amino acid transporters and as molecular targets in thyroid cancer.
Bibliography:The Korean Society of Endocrinology
ISSN:2093-596X