25 Years of Proton Pump Inhibitors: A Comprehensive Review

Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell a...

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Bibliographic Details
Published inGut and liver Vol. 11; no. 1; pp. 27 - 37
Main Authors Daniel S Strand, Daejin Kim, David A Peura
Format Journal Article
LanguageKorean
Published 대한소화기학회 30.01.2017
Subjects
Indications
Pharmacokinetics
Proton pump inhibitors
Review
Risk
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Summary:Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell acid secretion, there are slight differences among PPIs relating to their pharmacokinetic properties, metabolism, and Food and Drug Administration (FDA)-approved clinical indications. Nevertheless, each is effective in managing gastroesophageal reflux disease and uncomplicated or complicated peptic ulcer disease. Despite their overall efficacy, PPIs do have some limitations related to their short plasma half-lives and requirement for meal-associated dosing, which can lead to breakthrough symptoms in some individuals, especially at night. Longeracting PPIs and technology to prolong conventional PPI activity have been developed to specifically address these limitations and may improve clinical outcomes. (Gut Liver 2017;11:27-37)
Bibliography:Korean Society of Gastroenterology
ISSN:1976-2283