독시라민 과다복용에 의한 횡문근 융해 및 급성 신부전 2례

Doxylamine succinate is an antihistamine used primarily as a sleep-induction. It can be gotten without a doctor’s prescription in Korea, so it’s overdoses were frequently encountered. There were several reports that the overdoses of doxylamine might cause rhabdomyolysis, but few cases have been repo...

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Published in대한임상독성학회지 Vol. 2; no. 1; pp. 15 - 19
Main Authors 정재권, Jae Kwon Jung, 김성호, Sung Ho Kim, 김인식, In Seek Kim, 김선웅, Seon Woong Kim, 주동욱, Dong Wook Ju, 이덕현, Duk Hyun Lee, 김종근, Jong Kun Kim
Format Journal Article
LanguageKorean
Published 대한임상독성학회 30.06.2004
Subjects
Acute Renal Failure
ARF
Doxylamine
Rhabdomyolysis
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Summary:Doxylamine succinate is an antihistamine used primarily as a sleep-induction. It can be gotten without a doctor’s prescription in Korea, so it’s overdoses were frequently encountered. There were several reports that the overdoses of doxylamine might cause rhabdomyolysis, but few cases have been reported that it is related to acute renal failure (ARF). In cases that ARF occur, most of them are not severe enough to require hemodialysis. We experienced two cases of severe rhabdomyolysis complicating ARF after doxylamine overdose and treated with hemodialysis. Clinicians should be aware of the potentially lethal complications of rhabdomyolysis in patients who ingest doxylamine succinate and the needs for prompt intervention and careful assessment of renal function.
Bibliography:Korean Society of Clinical Toxicology
ISSN:1738-1320