Case Reports : A Case of Eosinophilic Polymyositis Treated with Immunosuppressants

• Published in: Journal of rheumatic diseases Vol. 22; no. 5; pp. 308 - 312
• Main Authors: 최정호, Jung Ho Choi, 강지현, Ji Hyoun Kang, 온리휘, Lihui Wen, 이정원, Jeong Won Lee, 이경은, Kyung Eun Lee, 박동진, Dong Jin Park, 박용욱, Yong Wook Park, 김태종, Tae Jong Kim, 이신석, Shin Seok Lee
• Format: Journal Article
• Language: Korean
• Published: 대한류마티스학회 31.10.2015
• Subjects: Eosinophilic myositis; Immunosuppressants; Myositis
• ISSN: 2093-940X

저자들은 사지의 부종, 근육통 및 근력저하를 주소로 내원한 환자를 호산구성 다발근염 진단 하에 고용량 글루코코르티코이드 치료를 시행하였으나, 이에 충분한 반응을 보이지 않아 면역억제제를 추가로 사용하여 성공적으로 치료한 호산구성 다발근염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Eosinophilic polymyositis is a rare form of inflammatory muscle disease associated with peripheral blood and/or tissue eosinophilia. Most patients respond to glucocorticoids, however some show poor prognosis, leading to mortality. A 28-year-old female was admitted to our hospital because of myalgia and motor weakness of the upper and lower extremities. Laboratory findings showed significantly elevated levels of muscle enzymes and inflammatory lesions in both thigh muscles were demonstrated on magnetic resonance imaging. A diagnosis of eosinophilic polymyositis was based on histological findings, which showed diffuse eosinophilic infiltration into perivascular spaces in the endomysium and perimysium, and necrosis of myofibers. High-dose methylprednisolone treatment improved the clinical symptoms and muscle enzymes. However, on tapering the glucocorticoid dose, clinical and laboratory findings were exacerbated. After the addition of methotrexate and azathioprine, the symptoms and muscle enzymes recovered without relapse. Here, we report on a case of eosinophilic polymyositis, which responded to immunosuppressants. (J Rheum Dis 2015;22:308-312)