Clinical Research Article : The effect of combination treatment using palonosetron and dexamethasone for the prevention of postoperative nausea and vomiting versus dexamethasone alone in women receiving intravenous patient-controlled analgesia
Background: The purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl. Methods: In this randomized, double-blinded,...
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Published in | Korean journal of anesthesiology Vol. 68; no. 3; pp. 267 - 273 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Korean |
Published |
대한마취통증의학회(구 대한마취과학회)
30.06.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Background: The purpose of this study was to evaluate the effect of palonosetron combined with dexamethasone for the prevention of PONV compared to dexamethasone alone in women who received intravenous patient-controlled analgesia (IV-PCA) using fentanyl. Methods: In this randomized, double-blinded, placebo-controlled study, 204 healthy female patients who were scheduled to undergo elective surgery under general anesthesia followed by IV-PCA for postoperative pain control were enrolled. Patients were divided into two groups: the PD group (palonosetron 0.075 mg and dexamethasone 5 mg IV; n = 102) and the D group (dexamethasone 5 mg IV; n = 102). The treatments were given after the induction of anesthesia. The incidence of nausea, vomiting, severity of nausea, and the use of rescue anti-emetics during the first 48 hours after surgery were evaluated. Results: The incidence of PONV was significantly lower in the PD group compared with the D group during the 0.24 hours (43 vs. 59%) and 0.48 hours after surgery (45 vs. 63%) (P < 0.05). The severity of nausea during the 6.24 hoursafter surgery was significantly less in the PD group compared with the D group (P < 0.05). The incidence of rescue antiemetic used was significantly lower in the PD group than in the D group during the 0.6 hours after surgery (13.1 vs. 24.5%) (P < 0.05). Conclusions: Palonosetron combined with dexamethasone was more effective in preventing PONV compared to dexamethasone alone in women receiving IV-PCA using fentanyl. |
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Bibliography: | The Korean Society of Anesthesiologists |
ISSN: | 2005-6419 2005-7563 |