Communication : Human Adenovirus Type 5 as a Delivery Vector is Not Neutralized in Field Serum Samples of Cattle, Pig, and Goat of Republic of Korea

Human adenovirus type 5 (hAd5) vectors have been demonstrated to be useful vehicles for gene expressions in animals. However, it has not been reported whether hAd5 transduction might be hampered in the sera of livestock animals inRepublic of Korea. We collected 205 samples of livestock animals, such...

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Bibliographic Details
Published inJournal of bacteriology and virology Vol. 44; no. 3; pp. 269 - 273
Main Authors Su Mi Kim, Hyang Sim Lee, Kwang Nyeong Lee, Jong Hyeon Park, Young Joon Ko, Byoung Han Kim
Format Journal Article
LanguageKorean
Published 대한바이러스학회 30.09.2014
Subjects
Antibody
Human adenovirus type 5
Korea
Serum
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Summary:Human adenovirus type 5 (hAd5) vectors have been demonstrated to be useful vehicles for gene expressions in animals. However, it has not been reported whether hAd5 transduction might be hampered in the sera of livestock animals inRepublic of Korea. We collected 205 samples of livestock animals, such as pig (n=84), cattle (n=84), and goat (n=37)in Korea. The neutralizing antibody (NAb) titers to hAd5 virus were less than 15 in most of samples. Only 8% of goatsamples had a NAb titer of 15 or 30. Thus, we showed that hAd5 virus was not neutralized in sera from cattle, pig, andgoat, and suggest that the hAd5 vector could be used for the effective delivery of vaccines or proteins in livestockanimals in the field.
Bibliography:The Korean Society of Virology
ISSN:1598-2467