Propylthiouracil에 의한 Antineutrophil Cytoplasmic Antibody 양성 괴저성 농피증 1예

• Published in: Journal of rheumatic diseases Vol. 21; no. 3; pp. 162 - 165
• Main Authors: 이지연, Ji Yeon Lee, 이지민, Ji Min Lee, 이태한, Tae Han Lee, 정혜진, Hye Jin Jeong, 최고, Go Choi, 채진녕, Jin Nyeong Chae, 김지민, Ji Min Kim, 김상현, Sang Hyon Kim
• Format: Journal Article
• Language: Korean
• Published: 대한류마티스학회 30.06.2014
• Subjects: ANCA; Propylthiouracil; Pyoderma gangrenosum
• ISSN: 2093-940X

ANCA 양성 괴저성 농피증은 PTU 복용 시 발생할 수 있는 드문 합병증이나 발생 가능함을 인지하여야 하고, 괴저성 농피증 환자에서 기저 질환뿐만 아니라 약물 복용력 확인이 반드시 필요하다. Pyoderma gangrenosum (PG) is a rare disease that causes chronic skin ulcers, and it has recently been known to be related to changes in the immune system such as dysfunction of neutrophils. Over 50% of patients with PG have an underlying systemic disease, and rarely are there various medicines causing the disease, including iodide, bromide, and isotretinoin. A 49-year-old man had recurrent skin ulcers in his lower extremities. He had a history of taking Propylthiouracil (PTU) for 10 years as a treatment for Graves` disease. Here, we describe a case of PTU-induced ANCA positive PG in a patient with hyperthyroidism, who has been improved after the cessation of PTU.