Lack of Association between PTPN22 Gene +1858 C＞T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population

• Published in: Annals of dermatology Vol. 26; no. 1; pp. 88 - 91
• Main Authors: Halit Akbas, Selma Bakar Dertlioglu, Fuat Dilmec, Ahmet Engin Atay
• Format: Journal Article
• Language: Korean
• Published: 대한피부과학회 28.02.2014
• Subjects: Polymerase chain reaction-restriction fragment length polymorphism; PTPN22 gene; Vitiligo
• ISSN: 1013-9087; 2005-3894

Background: Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C＞T single nucleotide polymorphism (rs2476601) has been shown to be associated with various autoimmune disorders. Objective: The aim of this study was to investigate whether the PTPN22 gene +1858 C＞T single nucleotide polymorphism is associated with susceptibility to generalized vitiligo in a Turkish population. Methods: One hundred and seven patients with generalized vitiligo, and one hundred and twelve gender-, age-, and ethnic-matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction- restriction fragment length polymorphism. Results: The PTPN22 +1858 C＞T genotype and allele frequencies of the generalized vitiligo patients did not differ significantly from those of healthy controls. Conclusion: We found no association between the PTPN22 +1858 C＞T gene polymorphism and vitiligo susceptibility in Turkish generalizedvitiligo patients. (Ann Dermatol 26(1) 88∼91, 2014)