장기간 Amlodipine 복용 후 발생한 심한 잇몸 과증식

• Published in: The Korean journal of medicine Vol. 82; no. 5; pp. 623 - 627
• Main Authors: 이성진, Sung Jin Lee, 정영국, Young Kuk Chung, 이해림, Hae Lim Lee, 최수진, Su Jin Choi, 조성연, Sung Yeon Cho, 최현주, Hyun Joo Choi, 김형욱, Hyung Wook Kim
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.05.2012
• Subjects: Amlodipine; Calcium-channel blocker; Gingival overgrowth; 암로디핀; 잇몸 과증식; 칼슘통로 차단제
• ISSN: 1738-9364

Amlodipine is one of the most commonly used calcium-channel blockers for the management of hypertension in Korea. Gingival overgrowth is an infrequent complication in patients receiving amlodipine treatment. A 52-year-old man on an amlodipine regimen of 10 mg/day for 25 months sought medical attention because of gradually progressive gingival enlargement. Examination of the oral cavity revealed severe gingival overgrowth. We stopped the amlodipine treatment and recommended the maintenance of good oral hygiene and a gingivectomy. Histological findings of the gingivectomy were typical of drug-induced gingival overgrowth, including epithelial thickening with proliferation, acanthosis with elongated rete ridges, and focal parakeratosis. A marked reduction in gingival overgrowth was evident 1 month after the gingivectomy and cessation of amlodipine. This report describes the case of a 52-year-old man who developed severe and histologically confirmed amlodipine-induced gingival overgrowth. (Korean J Med 2012;82:623-627)