Tranexamic Acid 투여 후 발생한 양측성 급성 신피질 괴사

• Published in: The Korean journal of medicine Vol. 80; no. 6; pp. 723 - 728
• Main Authors: 박주호, Joo Ho Park, 강민규, Min Kyu Kang, 나운태, Woon Tae Na, 송인걸, In Girl Song, 정장한, Jang Han Jung, 윤세희, Se Hee Yoon, 윤성로, Sung Ro Yun
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.06.2011
• Subjects: Acute kidney failure; Anuria; Kidney cortex necrosis; Tranexamic acid; 무뇨; 신부전; 신피질 괴사
• ISSN: 1738-9364

저자들은 Tranexamic acid 투여 후 갑작스런 혈소판 수 저하를 보이면서 발생한 양측성 급성 신피질 괴사 환자 1예를 경험하였기에 보고하는 바이다. Acute renal cortical necrosis is an anuric form of acute renal failure. We experienced a case of renal cortical necrosis complicated by tranexamic acid administration. To our knowledge, only three cases of renal cortical necrosis have been reported worldwide. A 49-year-old man was referred with hemothorax and multiple bone fractures following a traffic accident. Tranexamic acid, and hemocoagulase were injected three times a day. After the 4th dose of hemostatics, anuria developed abruptly, the platelet count decreased to 84,000 /μL, and the serum creatinine was increased to 2.56 from 1.06 mg/dL. On the 4th Intensive Care Unit (ICU) day, computed tomography (CT) showed bilateral renal cortical necrosis with normal renal arteries and aorta. The oliguria persisted for 14 days and temporary hemodialysis was performed. The serum creatinine had decreased to 2.12 mg/dL 8 months after discharge. (Korean J Med 2011;80:723-728)