강직성척추염에 동반된 만성 골수성백혈병

• Published in: Journal of rheumatic diseases Vol. 17; no. 4; pp. 417 - 421
• Main Authors: 이재호, Jae ho Lee, 박성환, Sung Hwan Park, 박경수, Kyung Su Park, 김호연, Ho Youn Kim, 최우형, Woo Hyung Choi, 전병연, Byoung Yeon Jun, 민진수, Jin Soo Min, 김세원, Sei Won Kim, 정연오, Yeon Oh Jeong, 지은혜, Eun Hye Ji, 박하욱, Ha Wook Park
• Format: Journal Article
• Language: Korean
• Published: 대한류마티스학회 30.12.2010
• Subjects: Ankylosing spondylitis; Chronic myelogenous Leukemia; Imatinib
• ISSN: 2093-940X

Ankylosing spondylitis (AS) is occasionally accompanied by hematological malignancies such as myelodysplastic syndrome, acute myelogenous leukemia, or multiple myeloma. Chronic myelogenous leukemia (CML) is a myeloproliferative disorder associated with Philadelphia chromosome and is usually treated with imatinib, which inhibits tyrosine kinases. Although there have been reports of CML cases accompanied by several rheumatic diseases such as rheumatoid arthritis, Behcet`s disease, systemic sclerosis, or undifferentiated spondylopathy, no studies have reported a case of CML with AS. We experienced a 50-year-old male patient who presented with buttock and low back pain and was diagnosed with both AS and CML. Magnetic resonance imaging showed sacroiliitis along with abnormal marrow infiltration, and a bone marrow biopsy confirmed the CML diagnosis. He was treated with imatinib, which was effective for the CML but not for the AS. This is the first case report of AS accompanied by CML.