만성 C형간염 환자에서 페그인터페론 알파 2b 치료 중 동시 발생한 당뇨병성 케톤산증과 자가면역 갑상샘염 1예

• Published in: Clinical and molecular hepatology Vol. 16; no. 2; pp. 187 - 191
• Main Authors: 이윤나, Yun Nah Lee, 정승원, Soung Won Jeong, 임재희, Jae Hee Lim, 유양선, Yang Seon Ryu, 전성란, Seong Ran Jeon, 김상균, Sang Kyun Kim, 장재영, Jae Young Jang, 김영석, Young Seok Kim, 김부성, Boo Sung Kim, 노미오, Mi Oh Roh
• Format: Journal Article
• Language: Korean
• Published: 대한간학회 25.06.2010
• Subjects: autoimmune; chronic; Diabetes Mellitus; Hepatitis C; Interferon Alfa-2b; Thyroiditis; type 1; 만성C형바이러스간염; 자가면역성 갑상샘염; 제1형 당뇨병
• ISSN: 2287-2728; 2287-285X

Combined pegylated interferon and ribavirin therapy for chronic hepatitis C infection cause a wide range of side effects, including flu-like syndrome, hematological abnormalities, cardiovascular symptoms, gastrointestinal symptoms, pulmonary dysfunction, depression, and retinopathy. Interferon-alpha has been shown to be related to the development of various autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroid disease, and type 1 diabetes mellitus (DM). Type 1 DM and thyroid disease respectively develop in 0.08～2.61% and 10～15% of patients treated with combined interferon-alpha and ribavirin for chronic hepatitis C. The coexistence of type 1 DM and autoimmune thyroiditis was rarely reported. We report a case of a 33-year-old female patient with chronic hepatitis C who simultaneously developed diabetic ketoacidosis and autoimmune thyroiditis after treatment with pegylated interferon-alpha 2b and ribavirin.