Vasopressin and Vasopressin Receptor Antagonists

Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney. Vasopressin binds to V2 receptor and increas...

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Bibliographic Details
Published inElectrolyte & blood pressure : E & BP Vol. 6; no. 1; pp. 51 - 55
Main Author Yun Kyu Oh
Format Journal Article
LanguageKorean
Published 대한전해질학회 30.06.2008
Subjects
aquaporin 2
hyponatremia
vasopressin receptor antagonist
vasopressins
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Summary:Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney. Vasopressin binds to V2 receptor and increases the number of aquaporin-2 at the apical plasma membrane of collecting duct principal cells. That induces high water permeability across the membrane. Several non-peptide vasopressin receptor antagonists have been developed and are being studied primarily for treating conditions characterized by hyponatremia and fluid overload. Further studies are needed to determine how they are best used in these situations.
Bibliography:The Korean Society of Electrolyte Metabolism
ISSN:1738-5997
2092-9935