노인 환자에서 Dapsone 투여 후 호전된 IgA-associated Leukocytoclastic Vasculitis

• Published in: Chʻŏnsik mit alrerugi Vol. 27; no. 3; pp. 186 - 189
• Main Authors: 권재우, Jae Woo Kwon, 김민혜, Min Hae Kim, 박한기, Han Gi Park, 임경환, Kyung Hwan Lim, 김태완, Tae Wan Kim, 양민석, Min Suk Yang, 이소희, So Hee Lee, 권혁수, Hyouk Soo Kwon, 김덕인, Deok In Kim, 박창한, Chang Han Park, 손성욱, Seoung Wook Son
• Format: Journal Article
• Language: Korean
• Published: 대한천식알레르기학회 30.09.2007
• Subjects: dapsone; Henoch-Schonlein purpura; IgA; vasculitis
• ISSN: 1226-8739

We report a case of elderly patient with IgA-associated leukocytoclastic vasculitis who was successfully treated with dapsone. A 75-year-old Korean female patient who had suffered from asthma visited because of multiple purpura, vesicle, and bullae on her extremities. She also complained of pitting edema, especially on the lower extremities. She was diagnosed as IgA-associated leukocytoclastic vasculitis by skin biopsy and treated successfully with steroid. How-ever, skin lesions recurred after tapering steroid. We restarted high-dose steroid and the lesions showed improvement. However, skin lesions were refractory to lower-dose steroids, and also refractory to colchicine treatment. Dapsone (50 mg daily) induced dramatic improvement of her cutaneous vasculitis, proteinuria and edema. (Korean J Asthma Allergy Clin Immunol 2007;27:186-189)