Genetic Polymorphism of Glutathione S-transferase P1 and Breast Cancer Risk

• Published in: BMB reports Vol. 37; no. 5; pp. 582 - 585
• Main Authors: Sook Un Kim, Kyoung Mu Lee, Sue Kyung Park, Keun Young Yoo, Dong Young Noh, Kook Jin Choe, Sei Hyun Ahn, Ari Hirvonen, Dae Hee Kang
• Format: Journal Article
• Language: Korean
• Published: 생화학분자생물학회 30.09.2004
• Subjects: Alcohol consumption; Breast cancer; Genetic polymorphism; GSTP1
• ISSN: 1976-6696

To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted on Korean women. The study population consisted of 171 histologically confirmed incident breast cancer cases and 171 age-matched controls with no present or previous history of cancer. PCR-RFI,P was used for the GSTPI genotyping and statistical evaluations were performed using an unconditional logistic regression model. Postmenopausal women with the GSTPI Val allele were found to have a reduced risk of breast cancer (OR = 0.3, 95% CI = 0.10 -0.74). A significant interaction was observed between the GSTPI genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTPI Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95% CI = 1.05 -7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95% CI = 0.27 ? 0.93). Our findings suggest that the GSTPI polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.