Monoclonal Gammopathy of Undetermined Significance 를 동반한 베체트 병 ( Behcet`s Disease ) 1 예

• Published in: The Korean journal of medicine Vol. 51; no. 4; pp. 548 - 552
• Main Authors: 한성훈, Seong Hoon Han, 김정수, Jeung Su Kim, 김현대, Hyeon Dae Kim, 정성광, Sung Kwang Chung, 전영빈, Young Bin Jeon, 이윤우, Yun Woo Lee, 남경재, Kyung Jae Nam
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.10.1996
• Subjects: Behcet`s disease; Monoclonal gammopathy of undetermined significance
• ISSN: 1738-9364

The term "monoclonal gammopathy of undetermined significance (MGUS)" denotes the presence of a M-protein in patients without multiple myeloma, macroglobulinemia, amyloidosis, or other related disease. MGUS is characterized by a serum M-protein concentration <3.0g/dL, <5% plasma cells in the bone marrow, either a small amount of M-protein or none at all in the urine, absence of lytic bone lesion, anemia, hypercalcemia, and renal insufficiency, and, most importantly, stability of the M-protein and failure of development of additional abnormalities. Recently we experienced one ease of MGUS associated with Behcet`s disease confirmed by electrophoresis, immunoelectrophoresis and bone marrow biopsy. A 37-year-old woman was admitted to our hospital in 1991 because of migratory joint pain for 2 years. On physical examination oral and genital ulcers were found, and erythematous palpable tender subcutaneous nodules were found also in the forearms and legs. The level of IgG Κ fraction in the serum was 0.52g/dl and the bone marrow biopsy was normal. Initially she had been treated with ibuprofen, prednisolone, colchicine and azathioprine under the diagnosis of Behcet`s disease with MSUS. The concentration of serum M-protein after treatment of four years was 2.69g/dL and she complained only migratory pain in back and extremity, and easy fatigability. Lately she has been managed with the combination of colchicine and azathioprine.