급성 골수성 백혈병이 발생한 가족 1 예

• Published in: The Korean journal of medicine Vol. 45; no. 3; pp. 388 - 395
• Main Authors: 신현춘, Hyun Choon Shin, 이진학, Jin Hak Lee, 이혁표, Hyuk Pyo Lee, 엄태현, Tae Hyun Um, 조한익, Han Ik Cho, 박선양, Seon Yang Park, 안효섭, Hyo Seop Ahn, 김병국, Byoung Kook Kim, 김노경, Noe Kyoung Kim, 오경식, Kyoung Sik Oh, 류명수, Myoung Soo Lyou
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.09.1993
• Subjects: Congenital leukemia; Familial Leukemia; Leukemogenic factor
• ISSN: 1738-9364

Backgound: The genetic factors involved in the etiology of human leukmia have been discussed including the occurence of leukemia in twins, leukmia in relatives of leukemic patients, the relation of genotypes and phenotypes to leukemia, and the complication of leukemia in various congenital diseases associated with chromosomal abnormalties and/or immunodeficiencies, but there are many problems that remain to be clarified. Case: We experienced 2 cases of acute myelogenous leukemia within a family. Young brother and elderly sister whose father had been died of acute leukemia was diagnosed as AML (M4) and AML (M1), respectively. The sister aged 19 presented with dizziness and dyspnea was given Ara-c and Daunorubicin chemotheraphy but expired without response. Young brother aged 17 presented with fever and epistaxis was responded well to the same regimen chemotheraphy, in remission. But his leukemia was relapsed despite of following 2 cycles of consolidation chemotherapy, and died of 7 months after treatment. Known leukemogenic factor such as, radiation, drug, chemical exposure was excluded in these patient. Conclusion: Although about 130 cases of familial leukemia has been described to date in other countries, no case has been reported in Korea. So we report this case with brief review of the literiture.