실험연구 : 고양이에서 저산소혈증후 대기 혹은 100 % 산소소생시 뇌에너지 대사의 변화 : 생체내 31P 자기공명분광법을 이용한 연구

• Published in: Korean journal of anesthesiology Vol. 30; no. 5; pp. 509 - 515
• Main Authors: 박평환, Pyung Hwan Park, 조삼순, Sam Soon Cho, 최수주, Soo Joo Choi, 김종욱, Joung Uk Kim, 이대근, Tae Keun Lee, 이정희, Jung Hee Lee, 임태환, Tae Hwan Lim
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.05.1996
• Subjects: Brain; hypoxia; metabolism; pH. Ventilation; resuscitaion
• ISSN: 2005-6419; 2005-7563

Background: This study was purposed to study the effect of reoxygenation with room air as compared to FiO₂ 1.0 in a feline model subjected to hypoxemia followed by reoxygenation. Changes in the brain energy metabolism were investigated by P magnetic resonance spectroscopy(P MRS). Methods: Twelve cats were employed for this study and divided into two groups(6 cats each). Both groups were subjected to hypoxemia for 1 hr with FiO₂ 0.07 followed by reoxygenation for 2hrs. For group I, the reoxygenation was done by FiO₂ 1.0 and for group 2, by room air. Brain intracellular pH and the ratio of Pcr/Pi(phosphocreatine/inorganic phosphate) were calculated from the spectra acquired every 15 mimutes of the hypoxemia and reoxygenation periods. Results: The intracellular pH of the baseline were 7.07±0.01 and 7.04±0.01 for group 1 and group 2, respectively, and dropped to 6.89±0.04 and 6.83±0.06 during hypoxemia. For both groups, the intracellular pH returned to baseline values after 30 minutes of reoxygenation. The ratios of Pcr/Pi of the baseline were 2.41±0.21 and 2.47±0.15, for group 1 and group 2, and dropped to 0.77±0.10 and 0.70±0.11, respectively, during hypoxemia and recovered to the baseline values after 30 minutes of reoxygenation for both groups. For both pH and the ratios of Pcr/Pi, the differences between the groups were statistically insignificant. Conclusion: From this study, we can conclude that reoxygenation by room air is as effective as FiO₂ 1.0 in the feline model of hypoxemia investigated by P MRS. (Korean J Anesthesiol 1996; 30: 509-515)