Pyridostigmine 투여시기와 Vecuronium 에 의한 근이완의 회복과의 관계

• Published in: Korean journal of anesthesiology Vol. 31; no. 5; pp. 619 - 623
• Main Authors: 김성열, Sung Yell Kim, 한찬수, Chan Soo Han, 김일호, Il Ho Kim, 김천숙, Chun Sook Kim, 신재환, Jae Hwan Shin
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.11.1996
• Subjects: Antagonists; neuromuscular relaxants; pyridostigmine. Neuromuscular function; recovery. Neuromuscular relaxants; vecuronium
• ISSN: 2005-6419; 2005-7563

Background: The timing of administration may be an important factor in order to obtain maximal antagonizing effect of anticholinesterase on neuromuscular blockade. The objective of this study is to seek for the optimal administration time of pyridostigmine for reducing the recovery time of vecuronium. Methods: Thirty patients were devided into three groups,who were receiving intravenously pyridostigmine (0.2 mg/kg) at 10% (group 1), 20% (group 2) and 25% (group 3) recovery of Tl. The recovery indices (RI: time taken for Tl to recover from 25 to 75% of control) and recovery time (time taken for Tl to recover from 5% to 20, 25, 50 & 75%) in vecuronium (0.1 mg/kg) neuromuscular blockade were checked and compared between 3 groups using train of four stimulation with Relaxograph(Datex co., Finland). Results: The recovery time (T5-20, T5-25, T5-50, T5-75) was significantly faster in the group I than the group 3. But there were no significant differences in recovery indices (RI) between 3 groups. Conclusions: Provided there is a slightest evidence of spontaneous recovery, early administration of anticholinesterse will reduce the recovery time of nondepolarizing neuromuscular block. But it can not affect the dissociation rate of vecuronium (KD) and there were no significant differences in recovery indices. (Korean J Anesthesiol 1996; 31: 619-623)