척추마취시 Midazolam 으로 진정 후 Flumazenil 의 각성효과

• Published in: Korean journal of anesthesiology Vol. 27; no. 8; pp. 930 - 936
• Main Authors: 송경상, Kyung Sang Song, 박경희, Kyung Hee Park, 김광성, Kwang Sung Kim, 이강원, Kang Won Lee, 김종선, Jong Sun Kim, 박미경, Mee Kyung Park
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.08.1994
• Subjects: Benzodiazepine antagonist; Flumazenil; Midazolam; Spinal anesthesia
• ISSN: 2005-6419; 2005-7563

The effects of flumazenil, a benzodiazepine antagonist were evaluated in a clinical study in which midazolam (0.1 mg/kg) was used as a sedative agent during the spinal anesthesia. Sixty patient were divided into two groups as group F (n=30) and group S (n=30). Flumazenil 0.3 mg (3 mL) in group F and saline 3 mL in group S were administered at the end of surgery. Blood pressure, pulse rate, respiratory rate and oxygen saturation (SaO2) were checked just before and at, 5, 15, 30, 60 and 120 minutes after the administration of flumazenil or saline. Also we evaluated the level of conciousness and orientation in time and space. The results were as follows; 1) Changes in blood pressure, pulse rate and respiratory rate were not different between two groups, exeept SaO2 was which increased significantly in the flumazenil group. 2) The flumazenil group revealed improved level of consciousness and orientation in time and space which began 5 minutes after flumazenil and was maintained 30 minutes thereafter. 3) We could not observe the any side effects of flumazenil.