연령이 Thiopental 수면용량에 미치는 영향

• Published in: Korean journal of anesthesiology Vol. 16; no. 4; pp. 324 - 329
• Main Authors: 함영돈, Young Don Ham, 정용중, Yong Choong Chung, 강화자, Wha Ja Kang, 이두익, Doo Ik Lee, 신광일, Kwang II Shin
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.12.1983
• ISSN: 2005-6419; 2005-7563

For many years it has been known that the dosage of thiopental required to induce anesthesia depends on the age of the patient, but this information has resulted from clinical experience with the drugs rather than from planned study. In our study, to elucidate the influence of age on the sige of the sleeping dosage of thiopental, 144 patients who underwent minor orthopedic and gynecological operations were studied. This patients had no evidence of a disease other than that scheduled for operation and were within normal values in hematologic examination, liver funtion and kidney function. Using a simple "yes" or "no" verbal command response, as sleeping response, to a single bolus of thiopental in mg/kg body weight, we have attemtet to minimige uncontrollable factors such as cerebral perfusion, circulation time and plasms protein binding which would alter response to thiopental infusions Continued tO the 0nd POintB. The results were as follows: 1) There was no statistical difference in verbal command response to thiopental according to age in age groups below 59 years. 2) Compared with age groups below 59 rears, 60 ~79 yrs. group failed to respond to the verbal command in 33% by 2.2 mg/kg ana 100% by above 2.6 mg/kg. (p<0.05) 3) The Mean time for loss of verbal command response after thioBental injection was 27.4±10.3 seconds and 80.4% of theses patients lost lid reflex with a mean time of 41.7±9.1 seconds after thiopental injection. 4) All groups showed statistically non-significant alterations of systolic blood pressure and heart rate after injection of thiopental.