마취전처치제 Flunitrazepam ( Ro 5-4200 ) 과 Meperidine HC1 의 비교적 연구

• Published in: Korean journal of anesthesiology Vol. 7; no. 1; pp. 41 - 44
• Main Authors: 함병문, Byung Moon Ham, 곽일용, II Yong Kwak, 김용락, Yong Lac Kim, 최중입, Joong Lip Choi
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.06.1974
• ISSN: 2005-6419; 2005-7563

It has recently been reported that chemical evaluations of a new benzodiazepine derivative, flunitrazepam (Ro 5-4200) revealed promising effects as premedicant. We studied on effects of premedication by double blind technique comparing flunitrazepam (Ro 5-4200) 0.03mg/kg I.M. and meperidine HCI 1mg/kg I.M. in 300 cases of preoperative patient by random selection. The questionaire on drowsiness, sleepiness and awareness during transport to the operation theatre, as well as nausea and vomiting were checked by anesthetists who were ignorant of the given premedicant. Following results were obtained; 1) Flunitrazepam has excellent calming effects in preanesthetic period, inducing drowsiness and adequate rest. 2) Flunitrazepam prcduces good sleep the night before operation. 3) Flunitrazepam has lower incidence of nausea and vcmiting than that cf meperidine HCI.