고양이에서 Enflurane 농도에 따른 호흡기계 역학의 변화

• Published in: Korean journal of anesthesiology Vol. 33; no. 3; pp. 393 - 398
• Main Authors: 심지연, Ji Yeon Shin, 이병욱, Byung Wook Lee, 정월선, Wol Sun Jung, 김종욱, Jong Uk Kim, 박평환, Pyung Hwan Park, 이동명, Dong Myung Lee
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.09.1997
• Subjects: Anesthetics; compliance; enflurane. Lung; resistance; volatile
• ISSN: 2005-6419; 2005-7563

Background : Flow interruption technique has been used to measure respiratory system mechanics, and its prominent advantage is to partitionate the respiratory system resistance into airway and tissue component. In this study, we investigated the effects of varing concentrations of enflurane on respiratory system mechanics using flow interruption technique. Methods : Six cats, weighing 3.0∼3.6 kg were used. Pentobarbital sodium was injected intraperitonially and endotracheal intubation was followed. Intermittent mandatory ventilation was applied with Siemens Servo 900C ventilator. The inspiratory flow rate, tidal volume, and respiratory rate were fixed, and normocarbia(PaCO2; 30∼35 mmHg) was maintained throughout the experiment. The changes in the pressure and volume were recorded with Bicore CP100 pulmonary monitor at control, 0.5, 1, 1.5, and 2 MAC of enflurane. The data were transfered to a PC and analyzed by Anadat processing software. Respiratory system, airway and tissue viscoelastic resistances, and dynamic and static compliances were calculated. Results : Respiratory system resistances decreased up to 1 MAC of enflurane compared to the control value(p＜0.05), but there were no significant differences in the values of resistance among 1, 1.5, 2 MAC of enflurane. There were no significant differences in tissue viscoelastic resistances, and dynamic and static compliances with varying concentrations of enflurane. Conclusions : Enflurane significantly reduces the respiratory system resistance mainly by decreasing airway resistance. Tissue viscoelastic resistance and respiratory system compliances are not influenced by changes in concentration of enflurane. (Korean J Anesthesiol 1997; 33: 393∼398)