마취유도시 Propofol 의 정주속도 변화가 활력징후, 약용량 및 마취유도시간에 미치는 영향

• Published in: Korean journal of anesthesiology Vol. 33; no. 2; pp. 262 - 266
• Main Authors: 양정화, Jung Hwa Yang, 이승준, Seung Joon Lee, 길호영, Ho Yeong Kil, 이성우, Sung Woo Lee, 윤영준, Young Joon Yoon
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.08.1997
• Subjects: Anesthetics; induction; intravenous; propofol. Anesthetic technique
• ISSN: 2005-6419; 2005-7563

Background : Induction of anesthesia with propofol commonly associated with reduction in systemic arterial pressure, especially in elderly and high risk patients. This reduction is influenced by the dose and rate of propofol injection. The aim of this study was to examine the effect of different injection rate of propofol on vital signs, dose requirement and induction time during induction period. Methods : Unpremedicated one hundred and twenty ASA physical status I and II patients aged 20∼60 years scheduled for elective surgery were randomly allocated into one of four(150, 300, 600, 1200 ml/hr) groups according to speed of injection of propofol during induction period. Loss of verbal contact was taken as the end-point of induction. Vital signs, SpO2, dose requirement of propofol and induction time were checked. Results : As the injection rate of propofol became slower, there were significant reduction in induction dose and increase in induction time(P<0.05). For example, induction dose and time were 1.82 mg/kg, 223±58 sec in 150 ml/hr group and 3.14 mg/kg, 50±11 sec in 1200 ml/hr group, respectively. Also, decrease in systolic and diastolic pressure were less marked at lower injection rates. Conclusions : Slower injection of propofol produces less vital sign changes and dose requirement for the induction of anesthesia. (Korean J Anesthesiol 1997; 33: 262∼266)