Ercp 전처치로서 Midazolam, Ketamine 단독 투여와 병합 투여의 효과 비교

• Published in: The Korean journal of gastroenterology Vol. 34; no. 3; pp. 381 - 389
• Main Authors: 박상흠, Sang Heum Park, 김선주, Sun Joo Kim, 김은주, Eun Joo Kim, 이문호, Moon Ho Lee, 김홍수, Hong Soo Kim, 정일권, Il Kwun Chung, 김재한, Jae Han Kim, 오흥석, Heung Seok Oh, 한찬수, Chan Soo Han
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.11.1999
• Subjects: Combined premedication; ERCP; Ketamine; Midazolam
• ISSN: 1598-9992

Background/Aims: For prernedication of endoscopic retrograde cholangiopancreatography (ERCP), midazolam has been widely used. Combined effects of midazolam and ketamine have been reported to bring a good result in some operative cases. We evaluated the efficacy of the combined low dose administration of midazolam and ketamine as premedication for ERCP. Methods: Forty-three patients were divided into three groups: ketamine (K), midazolam (M), and combined group (MK). Blood pressure (BP), pulse rate (PR), electrocardiogram and O2 saturation (SaO2) were monitored. We accessed the patients level of consciousness, conditions, tolerance and satisfaction. Results: BP was significantly elevated after procedure in all groups. PR was not changed but SaO2 was slightly increased in K group. In M group, PR was significantly increased but SaO was not changed. However, all were not changed in MK group. K group was more deeply sedated than others. Significant difference was not noted among three groups in aspect of tolerance and easiness to patients during procedure with tendency to refusal for re-examination in K group. One case of PVC and two of paradoxical agitation were occurred in M group, and one of bradycardia was observed in K group. Conclusions: Combined administration of low dose ketamine and midazolam is an effective premedication for ERCP. (Kor J Gastroenterol 1999;34:381 - 389)