국내에서 보고된 Helicobacter pylori 제균요법의 분석

• Published in: The Korean journal of gastroenterology Vol. 34; no. 1; pp. 42 - 49
• Main Authors: 김병욱, Byung Wook Kim, 최명규, Myung Gyu Choi, 문성배, Sung Bae Moon, 김보경, Bo Kyoung Kim, 채현석, Hiun Suk Chae, 김재광, Jae Kwang Kim, 정인식, In Sik Chung, 선희식, Hee Sik Sun, 박두호, Doo Ho Park
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1999
• Subjects: Eradication; Helicobacter pylori; Pooled analysis
• ISSN: 1598-9992

Background/Aims: We aimed to identify the ideal regimen for Helicobacter pylori (H. pylori) eradication in Korea. Methods: We analyzed the reports on H. pylori eradication published in Korea from June 1991 to July 1998. We included only the reports containing defined protocols and therapeutic regimens, clinical records of at least 15 adult patients with peptic ulcer for each regimen, and assessment of eradication rates taken 4 weeks or more after completion of therapy. Intention-to-treat analysis (ITT) and per-protocol analysis (PPA) were performed. Compliance and side effects were evaluated. Results: Seven (53.8%) among 13 full articles and 7 (26.9%) among 26 abstracts satisfied the requisite inclusion criteria. Eradication rates of proton pump inhibitor (PPI) based triple 7-day regimen which was consistent with consensus guidelines were 80.6% (range 53.2-93.1%) by ITT and 90.0% (range 85.2-93.1%) by PPA. There was no statistical significance among the treatment durations (7, 10, 14 days) of PPI-based therapies. Compliance was higher in PPI-based regimens than in bismuth-based regimens (p=0.018). Side effects could not be evaluated because they were not clearly appeared in the reports. Conclusions: Reports which followed the consensus guidelines were rare. PPI-based triple 7-day regimen was consistent with consensus guidelines, but it is still unclear whether this regimen was ideal therapy for eradication of H. pylori in Korea. Seven days of duration may be enough for PPI based triple regimen. The studies on H. pylori eradication should follow the consensus guidelines. (Kor J Gastroenterol 1999;34:42 - 49)