정상인에서 단기간의 Indomethacin 경구 투여가 장 투과성에 미치는 영향

The side effects of non-steroidal anti-inflammatory drugs (NSAIDs) involve mainly gastroduodenal mucosal lesions, however, recent studies suggest that NSAIDs ingestion can cause also the small intestinal diseases, which are characterized sequentially by inflammation, ulceration, perforation, and dia...

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Published inThe Korean journal of gastroenterology Vol. 24; no. 5; pp. 989 - 995
Main Authors 이태광, 양진석, 최은수, 윤윤보, 방신호, 민경완, 박원, 김학산, Tae Kwang Lee, Jin Seok Yang, Eun Soo Choi, Yoon Bo Yoon, Shin Ho Bang, Kyeong Wan Min, Won Park, Hak San Kim
Format Journal Article
LanguageKorean
Published 대한소화기학회 01.01.1992
Subjects
Intestinal permeability
Non-steroidal anti-inflammatory drugs
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Summary:The side effects of non-steroidal anti-inflammatory drugs (NSAIDs) involve mainly gastroduodenal mucosal lesions, however, recent studies suggest that NSAIDs ingestion can cause also the small intestinal diseases, which are characterized sequentially by inflammation, ulceration, perforation, and diaphramatic disease. This study examined the change of intestinal permeability after short-term oral administration of indomethacin and co-administration of synthetic prostaglandin E1 analogue, Misoprostol, in healthy men, The subjects drank test solution containing Cr-EDTA(100 pCi), and this was followed by 10 hour urine collection. The amount of Cr-EDTA in the urine reflects non-mediated intercellular intestinal permeability. Indomethacin significantly increased intestinal permeability to 51Cr-EDTA, and co-administration of prostaglandin E, analogue significantly decreased this detrimental effect of indomethacin. These findings suggest that prostaglandins are involved in maintaining intestinal integrity in man.
Bibliography:Korean Society of Gastroenterology
ISSN:1598-9992