한국인의 위 Alcohol Dehydrogenase ( ADH ) 활성도 및 각종 H-2 길항제의 백서 위 ADH에 대한 영향

• Published in: The Korean journal of gastroenterology Vol. 24; no. 4; pp. 706 - 713
• Main Authors: 윤세진, 이동호, 김나영, 김용태, 정현채, 이효석, 윤용범, 송인성, 최규완, 김정룡, 이건욱, 최국진, Sei Jin Youn, Dong Ho Lee, Na Young Kim, Yong Tae Kim, Hyun Chae Jung, Hyo Suk Lee, Yong Bum Yoon In Sung Song, Kyu Wan Choi, Chung Yong Kim, Kun Wook Lee, Kuk Jin Choe
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1992
• Subjects: ADH; H2-Receptor antagonists; Korean; Rats
• ISSN: 1598-9992

We undertook this study to investigate possible sex-related difference of ADH activity and to determine how such a activity might be affeeted by long-term consumption of ethanol in man and to investigate the effect of H-2 receptor antagonist on gastric and hepatic ADH activities in rats. The subjects were the normal looking mucosa (n=27) and mucosa of lesion (n=21) from 21 male and 8 female at the time of surgery for advanced gastric cancer. In animal study, they were divided into seven different groups of forty-two rats. GroupI were normal control rats receiving water and food ad libitum. The other groups were consisted of GroupII (receiving cimetidine, 40 mg/Kg), GroupIII(ranitidine, 10mg/Kg), GroupIV (famotidine, 1,3mg/Kg), GroupV (nizatidine, 10mg/Kg), GroupVI (omeprazole, 1 mg/Kg), GroupVII (roxatidine, 5 mg/Kg). Each group was treated by above mentioned drugs for 7 days. The results are as follows: (continue...)