백서에서 기계적 담도폐쇄에 의한 HDL 대사 변화에 대한 연구

• Published in: The Korean journal of gastroenterology Vol. 24; no. 1; pp. 70 - 79
• Main Authors: 김종구, 안중기, 오명성, 최수미, 전창호, 안득수, Chong Kuh Kim, Jung Ki Ahn, Meung Sung Oh, Soo Mi Choi, Chang Ho Jeon, Deuk Soo Ahn
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1992
• Subjects: HDL Metabolism; Mechanical Biliary obstruction
• ISSN: 1598-9992

Extrahepatic biliary obstruction in humans and in rats leads to change of the total HDL and its subfractions. To study this mechanism author have used Sprague Dawley rat with transsected common bile duct to measure total HDL and HDL3 by dual precipitation method. we had observed those rats for 20 days. Other parameters for liver dysfunction also were studied. The results were as follows: 1) HDL3 is higher concentration than HDL2 inhuman plaema about over half amount of total HDL but our study in the control rats, total HDL consist of HDL, 89.7+4.5% and HDL3 10.1+ 1.7%. 2) There were significant (statistical) differences between high total HDL levels of postoperative 5th days group (O.G1) or high those of postoperative 20th days group (O.G5) and those of control group (p<0.01, p<0.05) but a linear increase of total HDL levels of operation groups were not observed. 3) The differences of HDL3 %(HDL3/T-HDL) between operation groups and control group or either sham operation groups were statistically significant (p<0.01, p0.01) and significant increase of HDL3 % of operation groups was observed (p<0.05). 4) The change of HDL3 % of operation groups were observed same pattern in the mechanical biliary tree obstructed rats such as the change of total bilirubin, spleen weight and AST/ALT ratio. These results suggest that high HDL3 levels can use as an indicator or a diagnostic marker of obstructive jaundice. 5) In studies of bile juice of operation groups, the HDL3 % of bile juice (84.04%) were higher than those of serum (51.76%) and it menas that the form of nascent HDL from liver is almost HDL3 Above results concluded that there were significant increase in the level of HDL3 in mechanical biliary tract obstruction of rats compare to HDL3 of normal rat and that is probably due to change of apolipoproteins and decrease activtiy of lecithine cholesterol acyl transferase.