위 선암에서 p53 종양억제 유전자 발현에 관한 면역 조직 화학적 연구

• Published in: The Korean journal of gastroenterology Vol. 30; no. 1; pp. 30 - 38
• Main Authors: 원용환, Young Hwan Won, 이옥재, Ok Jae Lee, 김영채, Young Chai Kim
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 21.11.1998
• Subjects: Gastric adenocarcinoma; p53 gene
• ISSN: 1598-9992

Background/Aims: Mutation and overexpression of the p53 gene have been noted in a wide range of human cancers and are thought to play a role in malignant transformation. The aim of this study is to assess the relationship between the p53 protein and the clinicopathologic factors of p53 in the gastric adenocarcinoma. Methods: We examined p53 expression in paraffin- embedded tissues from 192 gastric adenocarcinomas including 47 early gastric can<:ers with an avidin-biotin peroxidase rnethod, using monoclonal antibody against the p53 protein. Results: The positive staining reactivity was observed in 33 of 192(17.2%) gastric adenoc:arcinomas including 29 of 145(20.0%) advanced gastric cancers and 4 of 47(8.5%) early gastric cancers. The association between p53 protein expression and clinicopathological factors such as age, sex, tumor size, Borrmanns type, Laurens classification, Mings classification, and histologic differenciation was not observed. But the tendency that expression of p53 protein was rnuch prominent in advanced gastric cancer and advanced TNM stage. The rates of p53 expression were higher in the groups with lymph node metastasis(p0.02) and serosal invasion(p0.05) than the groups without lymph node metastasis and serosal invasion. Conclusions: It is considered tbat p53 protein expression has a possible role in progression and metastasis of gastric adenocarcinoma. (Korean J Gastroenterol 1997; 30:30 - 38)