기타 : 담즙산으로 유도된 백서의 췌장손상에 대한 Prostaglandin E1의 효과

• Published in: The Korean journal of gastroenterology Vol. 23; no. 2; pp. 557 - 562
• Main Authors: 김학산, Hak San Kim, 이봉휘, Bong Hwi Lee, 남홍우, Hong Woo Nam, 송형운, Hyung Woon Song, 지영구, Young Ku Jee, 이태광, Tae Kwang Lee, 양진석, Jin Suk Yang, 한창순, Chang Soo Han, 한길로, Kil Ro Han, 서정일, Jung Il Suh
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1991
• Subjects: Pancreatitis; Prostaglandin E2
• ISSN: 1598-9992

To elucidate the cytoprotective effect of prostaglandin on pancreatic injury, we measured the mortality rate, the degree of pancreatic necrosis, and serum amylase level after prostaglandin E, administration in acute experimental pancreatitis which was induced by the retrograde injection of 5% sodium taurocholate into the biliopancreatic duct of rat. Prostaglandin E, (100 ug/kg Body Weight) were injected subcutaneously after 1 and 6 hour later after taurocholate injection, and normal saline solution (1 ml) to the control group by same method. The obstained results were as follows: 1) The mortality rate upto 72 hour was not different (11%: VS 29 %) in both group, but mortality rate upto 96 hour was significantly reduced in prostaglandin group compared with that of control group (11% vs 58% p<0.05). 2) The mean serum level of anylase of control group was 773 +- 55.2U and that of prostaglanin group was 772 +- 61.1 U, which were not significantly different each other. 3) The degree of pancreatic necrosis was also reduced in prostaglandin group compared with control group. In conclusion, the present study suggest that prostaglandin E, will have a benefical effect on the course of acute pancreatic injury induced by sodium taurocholate.