급성간염에서 담낭벽 두께의 변화에 대한 연구

• Published in: The Korean journal of gastroenterology Vol. 20; no. 3; pp. 608 - 614
• Main Authors: 박영우, Young Woo Park, 최재성, Jae Sung Choi, 안정효, Jung Hyo Ahn, 문영수, Young Soo Moon, 유건, Gun Yu, 김관엽, Kwan Yeop Kim
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1988
• ISSN: 1598-9992

We have studied the gallbladder and its thickness by ultrasonography in 41 patients with acute hepatitis and 35 patients with chronic liver disease as control group. From 41 acute hepatitis patients, 33 (80.5%) had thickened GB wall. The average thickness in these patients was 4.66+2.52mm, which compared to control groups 2.34+0.86mm, was statistically significant. There were no significant differences in the GB wall thickness in etiologic classification of acute hepatitis (A, B, NANB type). The GB wall thickness measured at less than 1 week from the time when the symptoms were firstly noted was 7.67+0.58 mm, 5.75+2.22 mm at less than 2 weeks, 2.94+1.06 mm at less than 3 weeks. It was noted that as time progressed, the wall thickness showed a steady decrease, and after the 3 weeks period, it measured to 2.33+0.98 mm being close to the size of the control group. The mean GB wall thickness in those patients with the serum ALT level of greater than 500 IU/L measured on the average of the tenth day of the appearance of symptoms was 5.48+2.35mm compared to 3.37+1.70mm for the patients who were meausred on the average of the 16th day when the ALT level was at less than 500 IU/L. The greater GB wall thickness when the serum ALT level was in excess of 500 IU/L was most likely due to the fact that the measurement was done at the early period of the disease. When the serum bilirubin level was high, the GB wall thickness vas significantly increased, however the wall thickness was close to that of control group ivhcn the bilirubin level below 2.0 rng/dl. There was no statistical correlation between the serum alkaline phosphatase level and the GB wall thickness. In conclusion, most of the hepatitis patients showed a thickened GB wall in ultrasonography. This condition was severe at the clinical stage when the serurn ALT and bilirubin levels were high, but as the disease progressed to past the 3 weeks period, the GB wall normalized in most of the cases.