위궤양에 대한 Teprenone ( Selbex ) 의 효과

• Published in: The Korean journal of gastroenterology Vol. 19; no. 2; pp. 44 - 49
• Main Authors: 윤종만, Chong Mann Yoon, 범희승, Hee Seung Bom, 최성규, Sung Kyu Choi, 박일종, Il Chong Park, 박해옥, Hae Ok Park, 류종선, Jong Sun Rew, 양대현, Dae Hyun Rang, 조정곤, Jong Kon Cho
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1987
• ISSN: 1598-9992

The balance of mucosal defensive factors and aggressive factors is important for ulcerogenesis. Gastrointestinal mucus is a complex glycoprotein which is secreted from variable types of cells in the gastrointestinal tract. Glycoprotein plays an important role as a mucosal defensive factor.We have treated 30 cases of endoscopically diagnosed gastric ulcers with teprenone (Selbex) for the evaluation of the therapeutic efficacy. Every patient was treated with teprenone 50 mg t.i.d. for 8 weeks and underwent endoscopic, clinical and laboratory assessments before and after 8 weeks of the treatment. Aiajor symptoms of gastric ulcer have been improved in 2 out :30 cases (83.4%) after 8 weeks of the medication with teprenone. While, the improvement of gastric ulcer evaluated by endoscopy was observed in 21 out of 30 cases (70.0%). No significant side effects were observed except a mild elevation of SGOT in one patient.