HBsAg 양성 만성간염과 음성군과의 비교연구

• Published in: The Korean journal of gastroenterology Vol. 19; no. 1; pp. 122 - 128
• Main Authors: 유방현, Bang Hyun Liu, 양웅석, Ung Suk Yang, 이강희, Kang Hi Lee, 조중현, Joong Hyeon Cho, 백대근, Dae Kun Baik, 김성은, Seong Eun Kim
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 01.01.1987
• ISSN: 1598-9992

A clinical study on 71 cases of chronic hepatitis, proven by liver biopsy, and its contrasting feature according to HBsAg positivity was performed at Pusan National University Hospial from Mar. 1983 to Dec. 1986. The results were as follows; 1) Of the total 71 cases, involving 45 cases of chronic active hepatitis and 26 cases of chronic persistent hepatitis, male to female ratio was 5.5:1. The mean age of chronic active hepatitis with HBsAg was significantly lower than that of chronic acive hepatitis without HBsAg (p<0.001). 2) The incidence of HBsAg was 80.0% in chronic active hepatitis and 65.4% in chronic persistent hepatitis. 3) On admission, the chief complaints were fatigue, indigestion, epigastric and RUQ discomfortness, hepatomegaly, jaundice, and splenomegaly in order of frequency respectively. 4) On chemical liver function studies, chronic active hepatitis with HBsAg showed more increased value of serum AST, ALT than that of chronic hepatitis without HBsAg (p<0.05). 5) On radioisotope liver scan, hypertrophic pattern of liver and mild spleen visualization was the most common findings. 6) Liver biopsy findings showed the increased incidence of piecemeal necrosis and concomitant fibrosis in chronic active hepatitis than chronic persistent hepatitis, but no significant difference was found between HBsAg positive and negative chronic hepatitis.