발암원을 투여한 쥐에서 들기름이 대장 종양발생과 조직의 지방산 조성 및 Eicosanoids 생성에 미치는 영향

• Published in: BMB reports Vol. 27; no. 6; pp. 550 - 557
• Main Authors: 송지현, 박현서, Ji Hyun Song, Hyun Suh Park
• Format: Journal Article
• Language: Korean
• Published: 생화학분자생물학회 01.01.1994
• ISSN: 1976-6696

The study was to observe the effect of perilla oil rich in a-linolenic acid(18:3ω3) on the incidence of colorectal tumor and its relation to the levels of plasma TXB₂ and colonic mucosal PGE₂ and fatty acid profiles of colonic mucosal lipid and hepatic microsomal phospholipid in colon carcinogenesis. Male Sprague Dawley rats, at 7 weeks of age, were divided into 2 groups and intrarectally infused with saline or chemical carcinogen (methylnitrosourea, MNU) and fed 16% (w/w) fat diet containing one of dietary fats (beef tallow, com oil, perilla oil) for 30 weeks. Large number of tumors were found in the distal colon of MNU-treated rats by all fats and tumor incidence was lower in the rats fed perilla oil (57.7%) compared to those of com oil (82.1%) or beef tallow (87.5%) diet. The overall fatty acid profiles of colonic mucosal lipid and hepatic microsomal phospholipid reflected dietary fatty acids. The levels of C20:4 were similarly higher in tissues of beef tallow or com oil fed rats even though dietary levels of C18:2 were significantly different in two groups, which suggests that there might be some regulatory mechanism present to control the level of C20:4 in tissue. The decreased level of C20:4w6 and increased level of w3 fatty acids in perilla oil fed rats were associated well with the decreased levels of plasma TXB₂ and colonic mucosal PGE₂. Perilla oil rich in ω α-linolenic acid decreased the incidence of colon tumor possibly through modification of tissue fatty acid profile and eicosanoid synthesis.