항돌연변이 작용을 보이는 Flavonoid 인 galangin 의 마우스에서의 BP 대사의 영향

To elucidate the antimutagenic action mechanism of flavonoids against benzo(a)pyrene induced micronucleated polychromatic erythrocytes (MNPCEs), alterations of benzo(a) pyrene metabolism were studied. Galangin, a potent antimutagen and (-)-epicatechin, a weak one, were selected and orally administer...

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Published inBMB reports Vol. 24; no. 2; pp. 141 - 147
Main Authors 김희기, 김경호, 허문영, 김현표, Hee Kee Kim, Kyeong Ho Kim, Moon Young Heo, Hyun Pyo Kim
Format Journal Article
LanguageKorean
Published 생화학분자생물학회 01.01.1991
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Summary:To elucidate the antimutagenic action mechanism of flavonoids against benzo(a)pyrene induced micronucleated polychromatic erythrocytes (MNPCEs), alterations of benzo(a) pyrene metabolism were studied. Galangin, a potent antimutagen and (-)-epicatechin, a weak one, were selected and orally administered to ICR mice to compare the liver metabolic enzyme activities, arylhydrocarbon hydroxylase (AHH) and glutathione-s-transferase (GSH-T). These enzyme activities were not significantly changed between the flavonoid-treated groups and the control group. However, direct addition of galangin to the incubation mixture clearly inhibited arylhydrocarbon hydroxylase activity. These results were well correlated with the findings of the reduced metabolic conversion of [³H]-benzo(a)pyrene in vitro.
Bibliography:Korean Society for Biochemistry and Molecular Biology
ISSN:1976-6696