Abstract of Papers Presented at 1981 Annual Meeting ; Effect of High Fat Diet with and Without Ginseng on Lipid Metabolism in Rats

• Published in: BMB reports Vol. 14; no. 4; pp. 366 - 367
• Main Authors: Soen Muk Park, Joon Seung Jo
• Format: Journal Article
• Language: Korean
• Published: 생화학분자생물학회 01.01.1981
• ISSN: 1976-6696

The effect of a high level and type of dietary fat with and without ginseng on lipid metabolism in the liver and adipose tissue of rats was investigated. The animals were divided into five groups : group A was fed the control diet consisting by calorie of 12 % fat, groups B and C were fed a 45 % corn oil diet and groups D and E were fed a 45% butter fat diet. The diets for all groups were isonergetic (4.4 ㎉/g) but the diet for group A had a slightly lower density of energy (0. 5 ㎉/g) than those for other groups. All animals were fed ad libitum for forty days, For the last ten days of the period, ginseng extract prepared by methanol extraction of dried ginseng roots was given intraperitoneally to groups C and E at a does of 5 ㎎ per 100 g body weight, and the same volume of the saline solution to groups B and D. The body weight gain was not different statistically between high-fat diet groups and the control diet groups, but was substantially less in ginseng-treated groups C and E compard with groups B (corn oil) and D (butter fat). However, the liver mass and fat pad of adipose tissue with the ratios of liver and fat pad weight were more high -fat diet groups B and D than in the control diet group A, especially remarkable in group D (butter fat), And liver weight with the ratio of liver weight to body weight but not fat pad of adiopse tissue were lower in ginseng-treated groups C and E than in high-fat diet groups B and D. Liver total lipid, triacylglycerol and cholesterol, but not phospholipid, were markedly increased in high-fat diet groups B and D compared with the control group A, Among these, total lipid and triacylglycerol of group D (butter fat) were higher than those of group B (corn oil), The increase in liver cholesterol of high-fat diet groups was declined remarkably by administration of ginseng, but minor changes were noted about on the liver total lipid and triacylglycerol in high-fat diet groups by ginseng treatment. In other hand, the incorporation rates of acetate-^(14)C into lipid of liver and adipose tissue were significantly lower in high-fat, groups B and D than in the control group A, The incorporation into liver lipid was lower in group D (butter fat) than in group B (corn oil), while the incorporation into adipose tissue lipid was higher in group D (butter fat) compared with group B (corn oil), By administration of ginseng the incorporation into liver lipid in high-fat diet groups was increased slightly, However, the incroporation into adipose tissue lipid in high-butter fat groups, but not high-corn oil groups, showed dramatic rise in ginseng treated group E compared with group D. These results have generally indicated that long-feeding of high-fat diet might induce fat accumulation in the body and cause it to be decreased in lipogenesis in the liver and adipose tissue, From this result, butter fat diet is more effective than corn oil, and ginseng might act to reduce fat accumulation and cholesterol synthesis in the liver and stimulate lipogenesis in adipose tissue.