Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance m Salmonella Typhimurium

The efficacy of antibiotics and host defenses has been linked to the metabolic and redox states of bacteria. In this study we report that a stress-induced export pump belonging to the major facilitator superfamily effluxes citrate and iron from the enteric pathogen Salmonella Typhimurium to arrest g...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 110; no. 29; pp. 12054 - 12059
Main Authors Frawley, Elaine R., Crouch, Marie-Laure V., Bingham-Ramos, Lacey K., Robbins, Hannah F., Wang, Wenliang, Wright, Gerard D., Fang, Ferric C.
Format Journal Article
LanguageEnglish
Published National Academy of Sciences 16.07.2013
Subjects
Antibiotics
Cell growth
Citrates
Escherichia coli
Iron
Operons
Peroxides
Reactive oxygen species
Salmonella typhimurium
Transposons
Online AccessGet full text

Cover

More Information
Summary:The efficacy of antibiotics and host defenses has been linked to the metabolic and redox states of bacteria. In this study we report that a stress-induced export pump belonging to the major facilitator superfamily effluxes citrate and iron from the enteric pathogen Salmonella Typhimurium to arrest growth and ameliorate the effects of antibiotics, hydrogen peroxide, and nitric oxide. The transporter, formerly known as MdtD, is now designated IceT (iron citrate efflux transporter). Iron efflux via an iron-chelating tricarboxylic acid cycle intermediate provides a direct link between aerobic metabolism and bacterial stress responses, representing a unique mechanism of resistance to host defenses and antimicrobial agents of diverse classes.
ISSN:0027-8424
1091-6490