REVIEW ARTICLE: Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis

The oncogenic potential of human papillomaviruses (HPV) is well known in the context of cervical carcinoma; however, their role in the development of oesophageal squamous cell carcinoma (OSCC) is less clear. We aimed to determine the extent of the association between HPV infection and OSCC. A compre...

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Published inEpidemiology and infection Vol. 142; no. 6; pp. 1119 - 1137
Main Authors HARDEFELDT, H. A., COX, M. R., ESLICK, G. D.
Format Journal Article
LanguageEnglish
Published Cambridge University Press 01.06.2014
Subjects
Cancer
Esophagus
Gastroenterology
Human papillomavirus 16
Human papillomavirus 18
Infections
Papilloma
Polymerase chain reaction
Squamous cell carcinoma
Viruses
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Summary:The oncogenic potential of human papillomaviruses (HPV) is well known in the context of cervical carcinoma; however, their role in the development of oesophageal squamous cell carcinoma (OSCC) is less clear. We aimed to determine the extent of the association between HPV infection and OSCC. A comprehensive literature search found 132 studies addressing HPV and OSCC in human cases, and a meta-analysis was performed using a random-effects model. There was evidence of an increased risk of OSCC in patients with HPV infection [odds ratio (OR) 2·69, 95% confidence interval (CI) 2·05–3·54]. The prevalence of HPV in OSCC was found to be 24·8%. There was an increased risk associated with HPV-16 infection (OR 2·35, 95% CI 1·73–3·19). Subgroup analyses showed geographical variance, with Asia (OR 2·94, 95% CI 2·16–4·00), and particularly China (OR 2·85, 95% CI 2·05–3·96) being high-risk areas. Our results confirm an increase in HPV infection in OSCC cases.
ISSN:0950-2688
1469-4409