Investigation of salivary duct carcinoma

• Published in: Stomato-pharyngology Vol. 29; no. 2; pp. 183 - 188
• Main Authors: Mihashi, Yasuhito, Sueta, Takayuki, Takeshita, Morishige, Nakagawa, Takashi
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Stomato-pharyngology 10.06.2016
• Subjects: fine-needle aspiration; perineural invasion; recurrence/metastasis; salivary duct carcinoma; vascular invasion
• ISSN: 0917-5105; 1884-4316
• DOI: 10.14821/stomatopharyngology.29.183

Salivary duct carcinomas (SDCs) is a malignant salivary gland tumor with relatively rare and high grade malignancy. We treated seven SDC patients in our department in the period from 2006 to 2015 and retrospectively investigated the results of fine-needle aspiration cytology (FNA) and the relationships between pathological and immunohistochemical findings and the prognosis in SDC. The subjects were six males and one female and the average age of the patients was 64 years (range: 59-73 years). Six tumors occurred in the parotid gland and one in the submandibular gland. In 4 patients local recurrence or metastasis occurred, and three of them died. In preoperative FNA, six cases of seven SDC patients were Class V and only one case had been diagnosed as having SDC. For the immunohistochemistly findings, the positive rate of androgen receptor (AR), human epidermal growth factor type-2 (HER-2) and epidermal growth factor receptor (EGFR) were 86%, 57% and 71%, respectively. Furthermore, the average value of the MIB-1 labeling index was 31.8%. FNA is a useful examination to determine the malignancy in cases of SDC. In all cases that resulted in a local recurrence or distant metastasis, the common findings were vascular and/or perineural invasion. This finding is likely to be a prognostic factor.