The Number and Proportion of Vϒ9Vδ2 T Cells Rise Significantly in the Peripheral Blood of Patients After the Onset of Acute Coxiella burnetii Infection
We conducted serial studies on peripheral blood lymphocytes from four patients with acute Coxiella burnetii infection. These studies revealed that the proportion of ϒδ T cells in these patients significantly increased after the onset of disease (mean, 16%; range, 13%–30%) as compared with that in fi...
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Published in | Clinical infectious diseases Vol. 24; no. 2; pp. 261 - 264 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
The University of Chicago Press
01.02.1997
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Online Access | Get full text |
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Summary: | We conducted serial studies on peripheral blood lymphocytes from four patients with acute Coxiella burnetii infection. These studies revealed that the proportion of ϒδ T cells in these patients significantly increased after the onset of disease (mean, 16%; range, 13%–30%) as compared with that in five healthy controls (mean, 4%; range, 0.5%–7%; P < .0055) and that in five controls with pneumonia (mean, 2%; range, 1%–3%; P < .0014). Most of the ϒδ T cells from these patients expressed the Vϒ9Vδ2 gene product. During the acute phase of disease, most ϒδ T cells expressed the activation marker human leukocyte antigen DR but not CD25. During this phase, ϒ;δ T cell activation was higher than αβ T cell activation. Our findings indicate that ϒδ T cells are predominantly involved in the acute immune response to C. burnetii. |
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Bibliography: | ark:/67375/HXZ-WG7RJTCW-1 Reprints or correspondence: Dr. Reiner Ullrich, Medizinische Klinik, Abteilung Gastroenterologie, Universitätsklinikum Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany. istex:4CA5749CB0602DC8F0E11EE37E07ED68E8FC10C6 |
ISSN: | 1058-4838 1537-6591 |
DOI: | 10.1093/clinids/24.2.261 |