Hysteresis and bistability in a realistic model for $\rm IP_{3}$-driven$\rm Ca^{2+}$ oscillations
We present a new model for inositol triphosphate $\rm (IP_{3})$-induced cytosolic $\rm Ca^{2+}$ oscillations in non-excitable cells. The model includes the various $\rm Ca^{2+}$ in- and efflux pathways reported to exist in these cells. In particular, it features the complex regulation of the $\rm Ca...
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Published in | Europhysics letters Vol. 55; no. 5; pp. 746 - 752 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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EDP Sciences
01.09.2001
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Abstract | We present a new model for inositol triphosphate $\rm (IP_{3})$-induced cytosolic $\rm Ca^{2+}$ oscillations in non-excitable cells. The model includes the various $\rm Ca^{2+}$ in- and efflux pathways reported to exist in these cells. In particular, it features the complex regulation of the $\rm Ca^{2+}$ release from the endoplasmic reticulum (ER) by $\rm IP_{3},$ cytosolic $\rm Ca^{2+}$ and $\rm Ca^{2+}$ in the ER. Bifurcation analysis revealed that the model accurately predicts the cytosolic $\rm Ca^{2+}$ dynamics in a typical non-excitable cell. Diffusional coupling of this model in a two-dimensional network shows hysteresis and bistability in its collective dynamics. Depending on the strength of the diffusion constant, we find traveling or spiral waves as solutions of this system. |
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AbstractList | We present a new model for inositol triphosphate $\rm (IP_{3})$-induced cytosolic $\rm Ca^{2+}$ oscillations in non-excitable cells. The model includes the various $\rm Ca^{2+}$ in- and efflux pathways reported to exist in these cells. In particular, it features the complex regulation of the $\rm Ca^{2+}$ release from the endoplasmic reticulum (ER) by $\rm IP_{3},$ cytosolic $\rm Ca^{2+}$ and $\rm Ca^{2+}$ in the ER. Bifurcation analysis revealed that the model accurately predicts the cytosolic $\rm Ca^{2+}$ dynamics in a typical non-excitable cell. Diffusional coupling of this model in a two-dimensional network shows hysteresis and bistability in its collective dynamics. Depending on the strength of the diffusion constant, we find traveling or spiral waves as solutions of this system. |
Author | Koopman, W. J. H. Kappen, H. J. Willems, P. H. G. M. Torres, J. J. |
Author_xml | – sequence: 1 givenname: J. J. surname: Torres fullname: Torres, J. J. email: jtorres@onsager.ugr.es organization: Department of Medical Physics and Biophysics, University ofNijmegen Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands – sequence: 2 givenname: P. H. G. M. surname: Willems fullname: Willems, P. H. G. M. organization: Departments of Biochemistry and Cell Physiology, University of Nijmegen Geert Grooteplein Zuid 30, 6525 AD Nijmegen, The Netherlands – sequence: 3 givenname: H. J. surname: Kappen fullname: Kappen, H. J. organization: Department of Medical Physics and Biophysics, University ofNijmegen Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands – sequence: 4 givenname: W. J. H. surname: Koopman fullname: Koopman, W. J. H. organization: Departments of Biochemistry and Cell Physiology, University of Nijmegen Geert Grooteplein Zuid 30, 6525 AD Nijmegen, The Netherlands |
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Snippet | We present a new model for inositol triphosphate $\rm (IP_{3})$-induced cytosolic $\rm Ca^{2+}$ oscillations in non-excitable cells. The model includes the... |
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Title | Hysteresis and bistability in a realistic model for $\rm IP_{3}$-driven$\rm Ca^{2+}$ oscillations |
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