Hysteresis and bistability in a realistic model for $\rm IP_{3}$-driven$\rm Ca^{2+}$ oscillations
We present a new model for inositol triphosphate $\rm (IP_{3})$-induced cytosolic $\rm Ca^{2+}$ oscillations in non-excitable cells. The model includes the various $\rm Ca^{2+}$ in- and efflux pathways reported to exist in these cells. In particular, it features the complex regulation of the $\rm Ca...
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Published in | Europhysics letters Vol. 55; no. 5; pp. 746 - 752 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
EDP Sciences
01.09.2001
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Subjects | |
Online Access | Get full text |
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Summary: | We present a new model for inositol triphosphate $\rm (IP_{3})$-induced cytosolic $\rm Ca^{2+}$ oscillations in non-excitable cells. The model includes the various $\rm Ca^{2+}$ in- and efflux pathways reported to exist in these cells. In particular, it features the complex regulation of the $\rm Ca^{2+}$ release from the endoplasmic reticulum (ER) by $\rm IP_{3},$ cytosolic $\rm Ca^{2+}$ and $\rm Ca^{2+}$ in the ER. Bifurcation analysis revealed that the model accurately predicts the cytosolic $\rm Ca^{2+}$ dynamics in a typical non-excitable cell. Diffusional coupling of this model in a two-dimensional network shows hysteresis and bistability in its collective dynamics. Depending on the strength of the diffusion constant, we find traveling or spiral waves as solutions of this system. |
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Bibliography: | ark:/67375/80W-RP6MBQLW-7 istex:B0423A8AD2FC1667992D5A9D1D2E7FEFCA6E845D publisher-ID:6687 |
ISSN: | 0295-5075 1286-4854 |
DOI: | 10.1209/epl/i2001-00477-3 |