Characterization of SPECTRUM Variable Nicotine Research Cigarettes
Objective: To provide researchers an extensive characterization of the SPECTRUM variable nicotine research cigarettes. Methods: Data on cigarette physical properties, nicotine content, and harmful and potentially harmful constituents in the tobacco filler were compiled. Results: Data on physical pro...
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Published in | Tobacco regulatory science Vol. 2; no. 2; pp. 94 - 105 |
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Main Authors | , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Tobacco Regulatory Science Group
01.04.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Objective: To provide researchers an extensive characterization of the SPECTRUM variable nicotine research cigarettes. Methods: Data on cigarette physical properties, nicotine content, and harmful and potentially harmful constituents in the tobacco filler were compiled.
Results: Data on physical properties, concentrations of menthol, nicotine and minor alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons, ammonia, and toxic metals in the filler tobacco for all available varieties of SPECTRUM research cigarettes are provided. The
similarity in the chemistry and physical properties of SPECTRUM cigarettes to commercial cigarettes renders them acceptable for use in behavioral studies. Baseline information on harmful and potentially harmful constituents in research tobacco products, particularly constituent levels such
as minor alkaloids that fall outside typical ranges reported for commercial products, provide researchers with the opportunity to monitor smoking behavior and to identify biomarkers that will inform efforts to understand the role of nicotine in creating and sustaining addiction. Conclusions:
Well characterized research cigarettes suitable for human consumption are an important tool in clinical studies for investigating the physiological impacts of cigarettes delivering various levels of nicotine, the impact of reduced nicotine cigarettes on nicotine addiction, and the relationship
between nicotine dose and smoking behavior. |
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Bibliography: | 2333-9748(20160401)2:2L.94;1- |
ISSN: | 2333-9748 2333-9748 |
DOI: | 10.18001/TRS.2.2.1 |