Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentrati...

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Bibliographic Details
Published inScandinavian Journal of Infectious Diseases Vol. 43; no. 11-12; pp. 982 - 985
Main Authors Tsuji, Yasuhiro, Hiraki, Yoichi, Matsumoto, Kana, Mizoguchi, Akiko, Sadoh, Shinichi, Kobayashi, Tsutomu, Takemura, Yusuke, Sakamoto, Seisaburo, Morita, Kunihiko, Kamimura, Hidetoshi, Karube, Yoshiharu
Format Report
LanguageEnglish
Published Taylor & Francis 01.12.2011
Subjects
bacterial meningitis
cerebrospinal fluid
Linezolid
protein binding ratio
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Summary:We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.
ISSN:0036-5548
1651-1980
DOI:10.3109/00365548.2011.600327