Effect of surface grain boundary density on preosteoblast proliferation on titanium

Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium's cytocompatibility, discs of UG...

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Bibliographic Details
Published inMaterials Research Letters Vol. 8; no. 6; pp. 239 - 246
Main Authors Lowe, Terry C., Reiss, Rebecca A., Illescas, Patrick E., Davis, Casey F., Connick, Melanie C., Sena, Johnny A.
Format Report
LanguageEnglish
Published Taylor & Francis 02.06.2020
Subjects
Cell proliferation
grain boundary density
ultrafine grain titanium
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Summary:Studies since 2004 have shown that the cytocompatibility of ultrafine grain (UG) commercial purity (CP) titanium exceeds that of coarse grain (CG) CP titanium (Ti) by 30% to 20-fold. To isolate the factors affecting this large reported variability of CP titanium's cytocompatibility, discs of UG and CG titanium were fabricated with controlled texture and roughness. The discs were seeded with MC3T3-E1 pre-osteoblastic cells and cultured for 72 h. The proliferation of cells on polished UG-Ti exceeded unpolished CG-Ti 3.04-fold. Cell proliferation was found to correlate with a new biophysical parameter, the average grain boundary length per surface-attached cell. By eliminating the influences of texture and roughness we have isolated the positive correlation between MC3TE-E1 cell proliferation on titanium and grain boundary length per surface-attached cell.
ISSN:2166-3831
DOI:10.1080/21663831.2020.1744758